Serum Integrated Screening —
without NT sonography

(41989 & 41962)
  • Comprehensive two-test option when NT-certified sonography is unavailable
  • Overall Down syndrome detection rate for serum integrated screening is 86%, with an overall false positive rate of 4%.

First Trimester Prenatal Screen

(41980)
  • Single test conducted between 10 weeks, 5 days and 13 weeks, 6 days of gestation that screens for Down syndrome and trisomy 18
  • Requires an NT-certified sonogram
  • Detection rate of 80% for Down syndrome with a 5% overall false positive rate.

Sequential Integrated Screening —
with NT sonography

(41990 & 41968)
  • This comprehensive two-test screening offers the highest detection rates (90% for Down syndrome) coupled with the lowest false positive results (3%).
  • Testing is performed Monday through Friday, with results available within 48 hours of receipt. Integrated results released within 2-3 days of receipt of 2nd trimester specimen.
  • Requires first trimester nuchal translucency (NT) sonogram by an NT-certified sonographer. Results from the sonogram and the two-prenatal screens are integrated by the lab through a complex calculation process.

 

Which Screen Do I Order?

For patients presenting in the first trimester, order the Sequential Integrated Screening tests (41990 & 41968), if NT sonography is available.

For patients presenting in the second trimester, the traditional Quad Marker (41955) provides the highest DR and lowest FPR for a second trimester–only test.


SEQUENTIAL INTEGRATED SCREENING-with NTQUAD MARKER SCREEN
Benefit
Highest DR, lowest FPR,       results available in first trimester
Highest DR in
2nd trimester
Overall DS
Detection Rate
90%
80%
Overall DS FPR
3%
5%
Trisomy 18
Detection Rate
90%
80%
ONTD DR
80%
80%
Tests
1st trimester:
HCG, PAPP-A, NT
2nd trimester:HCG, uE3, AFP, Inhibin-A
2nd trimester:HCG, uE3, AFP, Inhibin-A
1st Specimen & NT       (sequential only)
10 weeks, 5 days –
13 weeks, 6 days
N/A
2nd Specimen
15 weeks, 0 days –
21 weeks, 6 days
15 weeks, 0 days –
21 weeks, 6 days
DS=Down syndrome; DR=detection rate; FPR=false positive rate; ONTD=open neural tube defect; PAPP-A=pregnancy-associated plasma protein A; HCG=human chorionic gonadotropin; NT=nuchal translucency; OAPR=odds of being affected given a positive result


Image of Test flow for Early Detect Prenatal Screening.

The laboratory also offers:

For more information

on our prenatal testing, please see:

 


Test flow for Early Detect Prenatal Screening.
Click to enlarge.